Speakers
Description
Aggression represents a complex behavioural phenomenon that emerges across multiple psychiatric conditions through the interaction of biological vulnerabilities and psychosocial influences. While clinical research has traditionally examined aggressive behaviours within specific diagnostic categories, there is growing recognition that transdiagnostic approaches may better illuminate the underlying cognitive-emotional mechanisms that drive aggressive responses across different conditions. This project aims to identify distinct aggression biosignatures through neuropsychobiological characterisation across diagnostic categories. All participants complete the standardised Q01 assessment protocol, comprising structured clinical interviews, self-report questionnaires, cognitive assessment, and a 3-Tesla MRI scan. The MRI protocol includes a structural sequence, resting-state fMRI, two task-based fMRI paradigms (exposure to aggressive and non-aggressive but arousing film clips), and a DTI sequence. So far, preliminary MRI data from 60 participants have been collected across diverse diagnostic categories, with substantial variance in aggressive behaviour (OAS-M range: 0-128; M = 14.2, SD = 16.8).