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Franka Timm (Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)20/04/2026, 14:45Poster
Psychiatric conditions are highly heterogeneous, yet reliable biomarkers to guide diagnosis and personalized treatment remain limited. Normative modeling is an emerging method that enables the quantification of individuals' deviations from the expected norm, moving beyond traditional case-control comparison. Within a connectome-based framework, we developed a large-scale normative model (NM)...
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Katharina J. Wenger (Translational Neuroimaging)20/04/2026, 14:45Poster
RACOON-AI Brain Tumor is a nationwide, multi-site NUM 3.0 initiative uniting neuro-oncology experts to advance imaging-based diagnosis, treatment planning, and monitoring of brain tumors. It addresses the gap between molecular tumor classification and current imaging. The 2021 WHO classification emphasizes molecular features not captured by conventional MRI, while standard imaging often cannot...
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Lorina Zapf (Universitätsklinikum Frankfurt - Klinik für Psychiatrie, Psychosomatik und Psychotherapie)20/04/2026, 14:45Poster
Psychiatric disorders are increasingly conceptualized as disturbances in dynamic networks in which psychological processes, symptoms, and neurobiological mechanisms interact over time. While pharmacological interventions such as esketamine show promising clinical effects in the treatment of depression, our understanding of how such treatments simultaneously influence psychological and...
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Cosimo Iaia (Goethe University Frankfurt)20/04/2026, 14:45Poster
The ARENA Language Dataset will provide a rich multimodal resource for studying language processing in the brain. We currently collect MEG and functional MRI data from 8 participants performing tasks varying in language context granularity, across 31 sessions. In the narrative task, participants listen to an entire audiobook in German (one chapter per session, 11 chapters). In the sentence...
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Paul Forbes (CoBIC)20/04/2026, 14:45Poster
Fasting has a systemic impact on the body and brain, especially in the metabolic and neural pathways implicated in depression. For example, fasting promotes stress reduction, stimulates autophagy and lowers both blood sugar and blood pressure. In this project, we aim to determine the effect of fasting in depression. We focus specifically on how potential improvements in symptoms following...
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Kanthida van Welzen (Max Planck Institute for Empirical Aesthetics)20/04/2026, 14:45Poster
Creativity, the ability to produce ideas that are both original and appropriate, is often studied via abstract tasks that overlook the critical role of domain-specific expertise. Furthermore, while quantitative assessment of creative responses has advanced in the verbal domain, it remains underexplored in musical creativity. This PhD project investigates how musical expertise shapes creative...
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Ulrike Noeth20/04/2026, 14:45Poster
A method for the calculation of synthetic FLAIR images based on quantitative T1 and T2 maps is described. It includes the suppression of (1) partial volume (PV) artefacts from CSF and (2) false positives arising from motion artefacts in the T2 map. Synthetic FLAIR images were compared to conventionally acquired FLAIR modalities.
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The proposed method may help to shorten quantitative (q)MRI... -
Aicha Bouzouina (AG NMET)20/04/2026, 14:45Poster
Background: Despite the strong interaction between insulin resistance and depression, the relevance of central insulin signalling on emotional processing is unknown.
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Methods: In a double-blind crossover design, we applied intranasal insulin (INI, 160 UI) or placebo and assessed Emotional processing using visual analogue scales (VAS), a facial emotion recognition task (FERT), and fMRI during... -
Alexandre Jeanne20/04/2026, 14:45Poster
This study investigates autism as a highly heterogeneous neurodevelopmental condition, and proposes a neuroanatomical stratification as a biologically grounded approach to better capture individual variability beyond behavioural measures.
We analysed MRI-derived cortical thickness data from 993 participants, including 512 autistic individuals aged 3–31 years, across three large European...
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Yue Sun (MEG Laboratory, Cooperative Brain Imaging Center, Goethe University Frankfurt)20/04/2026, 14:45Poster
The human brain aligns actions to temporal regularities in sound, yet natural sounds often contain multiple competing onsets within a single event. How these landmarks are integrated to guide synchronized action remains unclear. We examined motor synchronization to competing acoustic onsets in speech and non-linguistic signals. Participants synchronized their tapping to consonant–vowel...
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Carmen Uckermark (Goethe University Hospital Frankfurt, Department for Psychiatry, Psychotherapy and Psychosomatics, and Cooperative Brain Imaging Center - CoBIC, Frankfurt am Main, Germany)20/04/2026, 14:45Poster
Growing evidence implicates that metabolic dysregulation, particularly insulin resistance and low-grade inflammation, increase the risk for persistent alterations of brain function after infectious disease. The CARE-MIND study investigates the influence of central insulin signaling for neuropsychiatric impairments in patients suffering from Long-COVID. In a randomized, double-blind,...
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Franziska Müller (Department of Child and Adolescent Psychiatry, Cooperative Brain Imaging Centre (COBIC), University Hospital, Goethe University, Frankfurt am Main)20/04/2026, 14:45Poster
We present a novel analytical framework to predict which behavioral domains are related to a pharmacological drug based on its mechanism of action. As proof-of-concept, we predict the behavioral profile of methylphenidate (MPH), a drug frequently prescribed to manage ADHD-related symptoms. For MPH's targets (dopamine transporter, noradrenaline transporter, and serotonin 1A receptor), we...
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Dingrong Guo (Goethe University Frankfurt)20/04/2026, 14:45Poster
Visual perception requires integrating incoming contextual information with prior memories. Predictive processing theories propose that this integration is supported by the laminar architecture of the visual cortex and its interactions with the medial temporal lobe, particularly the hippocampus and entorhinal cortex. To examine these neural mechanisms, we acquired ultra-high-field 7T fMRI data...
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Seung-Goo Kim (Max Planck Institute for Empirical Aesthetics)20/04/2026, 14:45Poster
We present an ongoing study aimed at creating a large-scale multimodal dataset for the precise modelling of music-evoked emotions, titled "ManyMusic 🎶." The dataset is designed to (1) include 1,080 full-length musical pieces spanning diverse genres and eliciting a wide range of emotions, (2) extensively sample EEG, fMRI, and behavioural signals from selected individuals across multiple...
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Matthias Grabenhorst (Ernst Strüngmann Institute of the Max Planck Society)20/04/2026, 14:45Poster
Many choices are triggered by discrete events whose timing determines which options are rewarded. Without informative sensory evidence between events, behavior must rely on internal estimates of latent variables—most notably elapsed time and reward probability. Existing computational frameworks, including evidence-accumulation models, are not designed for this regime, leaving the principles of...
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Anna Zier20/04/2026, 14:45Poster
Previous studies in working memory have identified brain regions that temporarily store simple visual features like orientation or color. In contrast, it remains unknown which brain areas temporarily store information about how those features are bound into an object. Participants (N=20) performed four separate functional magnetic resonance imaging (fMRI) sessions. They memorized two objects...
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Markus Aswendt (Goethe University Frankfurt)20/04/2026, 14:45Poster
MRI is a key tool in translational neuroscience, enabling non-invasive investigation of brain structure and function across species. While human MRI benefits from standardized workflows, comparable tools for rodents remain limited, despite the critical role of mouse models in studying brain function and disease.
To address this gap, we developed AIDA (Atlas-based Imaging Data Analysis), an...
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Philipp Deutsch (Goethe University, Institute of Medical Psychology, Cooperative Brain Imaging Center)20/04/2026, 14:45Poster
Working memory capacity is limited, constraining memory precision. Chunking items into structured groups improves precision in other domains, but its role in visual working memory remains unclear. We tested whether people organize visual memories using geometric primitives (e.g., grouping symmetrically arranged gratings). In two whole-report experiments, participants memorized orientations of...
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Seyma Alcicek20/04/2026, 14:45Poster
IDH-wildtype glioblastoma is the most common primary malignant brain tumor in adults with poor prognosis. Tumor survival depends on glutathione (GSH) and cystathionine (Cth) for redox balance. This study aimed to quantify these metabolites in vivo as potential biomarkers. Fifteen patients with high-quality MEGA-sLASER MRS data at 3T were analyzed. GSH and GABA-Cth were measured in tumor...
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Johanna Rimmele (Max-Planck-Institut für empirische Ästhetik)20/04/2026, 14:45Poster
Slow, endogenous auditory cortex brain rhythms are hypothesized to track acoustic amplitude modulations during speech comprehension. The tracking may be modulated by temporal predictions from the motor system. However, direct evidence for the involvement of endogenous auditory and motor brain rhythms is lacking. Using magnetoencephalographic recordings (n=57) we show that endogenous peak...
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Tea Bogdanovic (MEG Laboratory, CoBIC, Goethe University), Mathias Groothuis (MEG Labor), Marlon Schütz (MEG-Lab at Goethe University)20/04/2026, 14:45Poster
How can we watch the human brain in action on the timescale of
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thought? Magnetoencephalography (MEG) offers a remarkable answer. By
measuring the tiny magnetic fields generated by neuronal activity, MEG
provides direct access to brain function with millisecond precision,
making it uniquely suited to study fast neural processes underlying
perception, cognition, language, and action.... -
Pegah Yahaghi (Department of Cognitive Neuropsychology, Max Planck Institute for Empirical Aesthetics)20/04/2026, 14:45Poster
Flow describes a state of deep absorption during skilled performance that is linked to intrinsic enjoyment and achievement, yet its neural basis remains poorly understood. Because musical performance reliably elicits flow, we used piano playing as a model to investigate associations between subjective flow and neurophysiology. EEG was recorded while 30 pianists performed a self-selected,...
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Antonia Ceric (MPIAE)20/04/2026, 14:45Poster
Language is processed in dual streams with left-hemispheric preference for phonemes and right-hemispheric preference for prosody. In both the phoneme and the prosody network, the posterior superior temporal sulcus (pSTS) acts as a main hub transforming continuous acoustic features into discrete perceptual categories. However, the causal role of pSTS and the network’s capacity for flexible...
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70. Mapping Structural Connectome Alterations to Underlying Molecular Signatures in Bipolar DisorderStefanie Fischer20/04/2026, 14:45Poster
Bipolar disorder (BD) is a severe affective disorder with recurrent mood episodes that is associated with large-scale brain network dysconnectivity and molecular vulnerability.
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We analysed 126 BD patients and 852 healthy controls using diffusion MRI-based structural connectomics and genome-wide genotyping, testing node-wise connectivity with robust regression for diagnostic effects and... -
Ana Clemente (Max Planck Institute for Empirical Aesthetics)20/04/2026, 14:45Poster
Expert performance reflects profound adaptations across sensory, cognitive, and motor systems, yet the neurobiological architecture of human expertise remains poorly understood. Using musicianship as a model of highly trained human performance, this project investigates what distinguishes the expert brain after years of intensive practice. Leveraging ultra-high-field MRI, we aim to deliver the...
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Rebekka Tenderra (MPI for Empirical Aesthetics)20/04/2026, 14:45Poster
Rather than learning everything from first principles, humans can exploit structural similarities across contexts, allowing knowledge acquired in one domain to be applied in another. Cognitive-computational research suggests this process is essential to human reasoning. Here we combine representational geometry analyses of task-based fMRI with cognitive tests to probe the neural basis of...
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Janniek Wester (Max Planck Institute for Empirical Aesthetics, Frankfurt am Main, Germany)20/04/2026, 14:45Poster
We are surrounded by voices (both natural and synthetic) of varying quality, which raises the question: does the brain process those voices differently? Building on research revealing the timing of neural correlates for voice characteristics (within 100 ms for physical traits such as gender and age, and after 350 ms for social attributes, Lavan et al., 2025), we hypothesized that perceived...
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Yu-Hsin (Fiona) Chang (Max Planck Institute for Empirical Aesthetics)20/04/2026, 14:45Poster
Musical skill learning involves the integration of motor, perceptual, and cognitive processes and varies widely across individuals. While prior research has shown training-related brain plasticity, less is known about how baseline neural activity predicts learning success. We conducted a longitudinal study in music novices undergoing 6 weeks of piano training, including monozygotic twins and...
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Alessio Giacomel (Cooperative Brain Imaging Centre (COBIC), University Hospital, Goethe University, Frankfurt am Main, Germany)20/04/2026, 14:45Poster
Aggression is a public health concern, particularly in adolescents and young adults, and comprises reactive (RA) and proactive (PA) subtypes with distinct behavioral profiles. We investigated neuroanatomical and molecular correlates of RA and PA in 670 adolescents from the FemNAT-CD cohort using structural MRI, vertex-wise cortical thickness analyses, and imaging transcriptomics. Higher RA...
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Anna Katharina Müller (Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy), Julia Frey (Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy), Leonie Polzer (Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy)20/04/2026, 14:45Poster
The Neurophysiology Lab of the Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy investigates biobehavioral mechanisms in neurodevelopmental disorders, with a particular focus on autism. By integrating multimodal neurophysiological methods, such as EEG and pupillometry, with clinical phenotyping, we examine interacting alterations across multiple levels: from...
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Johannes Kasper (CoBIC)20/04/2026, 14:45Poster
Theories of motor control predict that discrepancies between intended and observed outcomes are compensated. However, occasionally, opposite responses occur that “follow” a disturbance, the reason for which remains elusive.
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We investigated this paradoxical behavior in an MEG experiment employing a novel MEG-compatible musical instrument. 19 musicians performed an auditory pitch control task... -
Catherine Barnes-Scheufler (Department of Psychiatry, Psychosomatic Medicine and Psychotherapy)20/04/2026, 14:45Poster
Objectives: Attention-Deficit / Hyperactivity disorder (ADHD) persists into adulthood resulting in lasting cognitive deficits including impaired attention and working memory (WM), reportedly being at the core of behavioral symptoms and functional impairments. A reduced signal-to-noise ratio (SNR) of prefrontal cortical activity has been proposed in ADHD, which could be linked to deficits in...
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Bassem Hermila (Department of Child and Adolescent Psychiatry, University Hospital, Goethe University, 60528, Frankfurt am Main, Germany.)20/04/2026, 14:45Poster
Autism and ADHD frequently co-occur and share genetic architecture, but it remains unclear how shared versus condition-specific liability maps onto neuroanatomical variation. We integrated GWAS summary statistics for autism, ADHD, and both combined (neurodevelopmental diversity, NDD) with cortical gene-expression data from the Allen Human Brain Atlas to derive genetically informed cortical...
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Hendrik Kröger20/04/2026, 14:45Poster
Psychiatric disorders including ADHD, depression, and schizophrenia are associated with characteristic alterations in semantic language processing. Recent work demonstrates that fMRI activation patterns in healthy individuals during naturalistic language processing share similarity with large language model (LLM) internal representations. Whether this alignment differs in clinical populations...
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Andrei Manzhurtsev20/04/2026, 14:45Poster
Brain metastases are the most common malignant brain tumors in adults, but response to immune and targeted therapies remains unpredictable. This study explores non-invasive metabolic imaging using edited MRS combined with qMRI to quantify lactate (Lac), glutathione (GSH), and GABA in vivo. Twelve patients underwent 3T MRI, MRS, and qMRI. Spectra were acquired in tumors and contralateral tissue...
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Dennis C. Thomas20/04/2026, 14:45Poster
Gadolinium-based contrast agents improve tumor visualization but pose risks such as toxicity and tissue retention. This study evaluated whether contrast enhancement can be predicted noninvasively from qMRI using deep learning and assessed the added value of QSM and PD.A nnU-Net was trained on 46 datasets and tested on 16 cases. Two models were compared: one using T1, T2*, PD, and QSM, and one...
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Antonio An (University Hospital Frankfurt), Ina Kuschel20/04/2026, 14:45Poster
Aggression represents a complex behavioural phenomenon that emerges across multiple psychiatric conditions through the interaction of biological vulnerabilities and psychosocial influences. While clinical research has traditionally examined aggressive behaviours within specific diagnostic categories, there is growing recognition that transdiagnostic approaches may better illuminate the...
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Seung-Cheol Baek (Max Planck Institute for Empirical Aesthetics)20/04/2026, 14:45Poster
Phonemes and prosodic contours are fundamental elements of speech used to convey complementary meanings. Perceiving these elements requires mapping variable acoustic cues onto discrete categories along ventral and dorsal speech streams. While traditional models make clear predictions, exactly where and when this acoustic-to-categorical mapping occurs remains unclear. Using...
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Felix Körber (People's Lab)20/04/2026, 14:45Poster
According to the predictive coding framework, mammalian brains make sense of the world by constantly comparing internal predictions with sensory input. Mismatch negativity, which reflects a mismatch of input and expectations, is influenced by mental disorders such as schizophrenia. While alterations in network dynamics could elucidate underlying causes of disorders, studying human network...
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Anya Dietrich (MEG Laboratory, CoBIC, Goethe University)20/04/2026, 14:45Poster
Resting-state electrophysiological activity encodes stable, individual-specific neural fingerprints that relate to cognitive emotion regulation. While such fingerprints are well established in MEG and fMRI, their stability and behavioral relevance in EEG remain unclear. Here, we examine sensor-level resting-state EEG spectral fingerprints in a deeply phenotyped cohort (N = 121), focusing on an...
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Henry Staub (Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)20/04/2026, 14:45Poster
Of patients suffering from depression, a minimum of 30% meet the criteria for difficult-to-treat depression. Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex sites (dlPFC) maximally anticorrelated with the subgenual anterior cingulate cortex (sgACC) improves outcomes, yet lacks quantitative optimization frameworks. Using network control...
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Eugen Wassiliwizky20/04/2026, 14:45Poster
What does it mean to perceive the world from an aesthetic attitude? This concept refers to a distinct mode of perception and engagement, characterized by focused attention, emotional sensitivity, and openness to the sensory and affective qualities of objects—often facilitating an aesthetic experience.
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In this neuroimaging study, we sought to identify the neural correlates of the aesthetic... -
Caroline Kellner (MPI for Empirical Aesthetics)20/04/2026, 14:45Poster
Speech and song are human vocal behaviors with partially different acoustic characteristics and underlying cognitive processes. Throughout evolution song has emerged as an oral tool for long-term information storage and transfer. However, it remains unclear which features of song facilitate this function.
We present preliminary results from an ongoing study that investigates how the...
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Hanna Seelemeyer20/04/2026, 14:45Poster
In autism, increased symptom severity typically relates to reduced adaptive functioning (daily living, social, and motor skills). Yet, some individuals exhibit high adaptive functioning despite pronounced symptoms (“adaptive resilience”), while others show the reverse (“adaptive vulnerability”). This study examined the neuroanatomical correlates of adaptive resilience/vulnerability, potential...
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Dimo Ivanov20/04/2026, 14:45Poster
We present our ongoing work to link brain perfusion with vascular structure, or angioarchitecture, using ultra-high-field 7 Tesla MRI. Perfusion reflects blood delivery to tissue, while angioarchitecture maps the arterial, venous, and microvascular pathways that enable that flow. The study combines arterial spin labelling (ASL) for cerebral blood flow with segmented multi-echo 3D EPI (ME3DEPI)...
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Kamil Piwowar (Goethe Universität)20/04/2026, 14:45Poster
Large language models enable the quantification of speech as embeddings in a multidimensional semantic space. We collected interview data of an ADHD group (n = 74; 40 men and 34 women; mean age = 35.8 years) and healthy controls (n = 23; 14 men and 9 women; mean age = 33.6 years). By modelling consecutive utterances as semantic trajectories, we found that the ADHD group showed greater...
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Marius Gruber20/04/2026, 14:45Poster
Network mapping has identified putative "causal" brain circuits for depression, yet deep phenotyping of these circuits in clinically depressed individuals remains lacking. This study presents a transdiagnostic, multimodal investigation of depression circuits using resting-state fMRI, diffusion-weighted imaging, and structural MRI from the Marburg-Münster Affective Disorders Cohort Study...
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Christian Kell (Goethe Universität)20/04/2026, 14:45Poster
In visuomotor control, the right hemisphere has been associated with visuospatial, and the left with visuotemporal processing. In right-handers, asymmetric bimanual tasks result in a preferred use of the left hand for spatial processing and of the right hand for temporal processing.
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We investigated interhemispheric interactions in 24 right-handers during asymmetric bimanual isometric...
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