Henry Staub
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)
Of patients suffering from depression, a minimum of 30% meet the criteria for difficult-to-treat depression. Repetitive transcranial magnetic stimulation (rTMS) targeting the left dorsolateral prefrontal cortex sites (dlPFC) maximally anticorrelated with the subgenual anterior cingulate cortex (sgACC) improves outcomes, yet lacks quantitative optimization frameworks. Using network control theory (NCT), we examined structural and functional controllability between dlPFC and sgACC in 972 participants (610 patients, 362 controls) from the MACS study. We computed controllability Gramians based on structural and functional connectivty for region-to-region control influence.
The dlPFC exerted control over sgACC (structural/functional), but more so over prefrontal/temporal-parietal and insular/cingulate regions. sgACC received maximal input from orbitofrontal/rostral ACC neighbors, not from the dlPFC. Control metrics based on structural and functional connectivity correlated (r=0.29,p<.001); control estimates were largely similar for MDD patients and controls. NCT partially supports anticorrelation targets and guides understanding of functional connectivity guided rTMS target selection.
Henry Staub
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)
Marius Gruber
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany; Institute for Translational Psychiatry, University of Münster, Münster, Germany)
Bita Shariatpanahi
(Department of Psychiatry and Psychotherapy, Phillips University Marburg, Marburg, Germany)
Kira Ahrens
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)
Paula Rehm
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)
Franka Timm
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)
Stefanie Fischer
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany)
Alina Buschhüter
(Department of Psychiatry and Psychotherapy, Phillips University Marburg, Marburg, Germany)
Tim Hahn
(Institute for Translational Psychiatry, University of Münster, Münster, Germany)
Tilo Kircher
(Department of Psychiatry and Psychotherapy, Phillips University Marburg, Marburg, Germany; Center for Mind, Brain and Behavior (CMBB), University of Marburg and Justus Liebig University Giessen, Germany)
Udo Dannlowski
(Institute for Translational Psychiatry, University of Münster, Münster, Germany; Bielefeld University, Medical School and University Medical Center OWL, Protestant Hospital of the Bethel Foundation, Department of Psychiatry)
Andreas Reif
(Goethe University, University Hospital, Department of Psychiatry, Psychotherapy and Psychosomatics, Frankfurt am Main, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology, Frankfurt, Germany)
Hamidreza Jamalabadi
(Department of Psychiatry and Psychotherapy, Phillips University Marburg, Marburg, Germany)
J. Repple
(Goethe University Frankfurt, University Hospital, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Germany; Goethe University Frankfurt, Cooperative Brain Imaging Center - CoBIC, Frankfurt, Germany; Institute for Translational Psychiatry, University of Münster, Münster, Germany)
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