Speaker
Description
IDH-wildtype glioblastoma is the most common primary malignant brain tumor in adults with poor prognosis. Tumor survival depends on glutathione (GSH) and cystathionine (Cth) for redox balance. This study aimed to quantify these metabolites in vivo as potential biomarkers. Fifteen patients with high-quality MEGA-sLASER MRS data at 3T were analyzed. GSH and GABA-Cth were measured in tumor subregions using Gannet, LCModel, and qMRI corrections. Tumors showed higher Cth and lower GABA+ compared to normal brain. GSH correlated positively with Cth and enhancing tumor fraction, and negatively with p53. No association was found with MGMT status, but lower GSH appeared in the mesenchymal subtype. Results indicate increased transsulfuration activity and highlight metabolic heterogeneity, supporting individualized tumor profiling.